Integral estimate of spatial distribution of 99mTc-HMPAO in brain of patients with mild cognitive changes
DOI:
https://doi.org/10.3103/S073527271412005XKeywords:
SPECT, brain, perfusion, cognitive changes, catastrophe, synchronizationAbstract
A new approach of quantitative analysis of images of the single photon emission computer tomography (SPECT) of brain aimed at determining the degree of mild cognitive impairment has been developed. The analysis is based on evaluation of the average gradient of radioactivity distribution over the transverse section of brain along the set direction, and also on the analysis of signal Fourier-spectra. The presented data indicate a possible emergence of the assembly-type catastrophe for brain perfusion depending on the level of cognitive disorders.
References
ROMANOVSKII, Y.M.; STEPANOVA, N.V.; CHERNAVSKII, D.S. Mathematical Models in Biophysics. Moscow: Nauka, 1975 [in Russian], 344 p.
CHEREZOV, A.E. General Theory of Cancer: Tissue Approach. Moscow: MGU, 1997 [in Russian], 252 p.
DEARY, I.J.; CORLEY, J.; GOW, A.J.; HARRIS, S.E.; HOULIHAN, L.M.; MARIONI, R.E.; PENKE, L.; RAFNSSON, S.B.; STARR, J.M. Age-associated cognitive decline. Br. Med. Bull., 2009, v.92, n.1, p.135-152, DOI: http://dx.doi.org/10.1093/bmb/ldp033.
JIM, H.S.L.; PHILLIPS, K.M.; CHAIT, S.; FAUL, L.A.; POPA, M.A.; LEE, Y.-H.; HUSSIN, M.G.; JACOBSEN, P.B.; SMALL, B.J. Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. J. Clin. Oncol., 2012, v.30, n.29, p.3578-3587, DOI: http://dx.doi.org/10.1200/JCO.2011.39.5640.
ZAKHAROV, V.V. Evolution of cognitive deficit: mild and moderate cognitive impairments. Neurology, Neuropsychiatry, Psychosomatics, 2012, n.2, p.16-21, DOI: http://dx.doi.org/10.14412/2074-2711-2012-376.
SOROKINA, I.B.; GUDKOVA, A.A.; GEKHT, A.B. Mild cognitive impairments caused by vascular cerebral disorders: diagnostics and principles of therapy. Trudnyi Patsient, 2010, n.3, p.56-60, http://t-pacient.ru/articles/6538/.
AKHUTINA, T.V.; MELIKYAN, Z.A. Neuropsychological Assessment: an overview of modern tendencies (dedicated to 110-th anniversary of A.R. Luria). Clinical Psychology and Special Education, 2012, n.2, p.17, http://psyjournals.ru/en/psyclin/2012/n2/54529.shtml.
KATAEVA, G.V. Stable patterns of distributions of the regional cerebral blood-flow and metabolic rate in human brain. Ph.D. Dissertation in Biological Sciences. St. Petersburg, 2008.
NIKOLOV, N.A.; ZALISNA, Y.D.; MAKEYEV, S.S. Quantitative analysis of brain SPECT with 99mTc-HMPAO in patients with mild cognitive changes. Proc. of IEEE 34th Int. Sci. Conf. on Electronics and Nanotechnology, ELNANO-2014, April 15–17, 2014, Kyiv, Ukraine. Kyiv: NTUU KPI, 2014, p.295-298.
BAK, PER; TANG, CHAO; WIESENFELD, KURT. Self-organized criticality. Phys. Rev. A, 1988, v.38, n.1, p.364-374, DOI: http://dx.doi.org/10.1103/PhysRevA.38.364.
KARMANOV, A.P.; MATVEEV, D.V. The concept of self-organized criticality as applied to the investigation of lignin biosynthesis dynamics. Chemistry of Plant Raw Material, 2001, n.2, p.31-37, http://www.chem.asu.ru/chemwood_old/volume5/2001_02/0102_031.pdf.
PALKINA, A.A.; BOLGOVA, I.I.; MUKHINA, V.I.; ET AL. Diagnostics of the anxiety level in the complex of psychological preparation of patient for MRT-examination. Promeneva Diagnostyka, Promeneva Terapiia, 2014, n.1–2, p.61-62.
THOMPSON, J.M.T. Instabilities and Catastrophes in Science and Engineering. John Wiley & Sons Inc., 1981, 254 p.
EBMEIER, K.P.; LAWRIE, S.M.; BLACKWOOD, D.H.; JOHNSTONE, E.C.; GOODWIN, G.M. Hypofrontality revisited: a high resolution single photon emission computed tomography study in schizophrenia. J. Neurol. Neurosurg. Psychiatry, 1995, v.58, n.4, p.452-456, DOI: http://dx.doi.org/10.1136/jnnp.58.4.452.
